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The Gt(ROSA)26Sor gene is interrupted by a DNA sequence encoding a constitutively active mutant human platelet derived growth factor receptor, alpha polypeptide, in which the aspartic acid at amino acid position 842 has been replaced by valine (D842V). The PDGFRA sequence is preceded by a loxP flanked cassette containing termination codons in all three reading frames. In the presence of cre recombinase, this STOP cassette is excised, permitting expression of the mutant receptor from the native Gt(ROSA)26Sor promoter. (J:145520)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
