LoxP sites were placed on either side of the exons that encode for the S5/S6 transmembrane domains of the gene followed by an FRT-flanked self-excising neomycin resistance cassette placed in the opposite transcriptional orientation. The neomycin cassette was excised through a cross with a Gt(ROSA)26Sor FLP strain on an unknown genetic background and the floxed exons were deleted through a cross with a Cre strain with a widespread pattern of expression on an unknown genetic background. Cre has been selectively bred away from the line. (J:169738)
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基础信息

模型ID
品系来源
等位基因类型
突变
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相关基因
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参考文献
129S6/SvEvTac
Targeted
Insertion, Intragenic deletion
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1
2
3

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标签摘要:
hm: 纯合子
ht: 杂合子
cn: 条件基因型
cx: 复合型:涉及多基因组
tg: 转基因
ot: 其他:半合子、不确定...
(F): 雌性
(M): 雄性
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N: 正常表型
(#): 上标括号内为相关疾病数量
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