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The tumor virus A (Tva) sequence disrupted with a lox-stop-lox cassette after the initiation codon, an IRES element and lacZ were inserted into intron 1 via homologous recombination. Cre mediated recombination results in expression of TVA and lacZ. Expression of TVA makes cells vulnerable to infection by RCAS (replication-competent sarcoma-leukosis virus long terminal repeat with splice acceptor) vector with Bryan-RSV polymerase and subgroup A envelope viruses (RCASBP(A)). (J:140423)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
