LoxP sites were inserted before exon7 and after exon 8 and an Frt flanked neo cassette was inserted upstream of the 5' loxP site via homologous recombination. Transient Flp expression resulted in deletion of the neo cassette. (J:140246)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count