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A neo cassette with a 5' loxP site was inserted upstream of exon 32 and an additional loxP site was inserted downstream of exon 32. Transient cre expression in ES cells was used to removed the neo cassette and exon 32 causing a frame shift and premature termination of translation. The absence of the long form of the protein was confirmed by western blot analysis on brain and heart extracts. (J:140030)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
