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A loxP-flanked neomycin selection cassette replaced the entire coding sequence of the two gene loci. PicoRNAs (piRNA) from the gene loci were not detectable by real-time PCR on RNA from the testes of homozygous mice. Also, piRNAs up to 7 kb upstream (piR-135965) and 8 kb downstream of the deleted region (piR-111581) were markedly decreased in the testes of male homozygotes. Expression of the L1 retrotransposon, a target of some of these piRNAs, was increased in the testes of these mice. (J:139921)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
