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A cre recombinase gene was driven by an alpha A crystallin promoter consisting of -282/+43 of the mouse Cryaa gene. Seven founder lines were generated using this construct, which in this line was coinjected with a tyrosinase minigene. Line 39 has expression of the transgene in lens fiber cells but not in the surrounding lens epithelium. Ectopic expression of the transgene was also detected in the retinal pigment epithelium and in the ciliary bodies of the eye. (J:90292)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
