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This transgene consists of a chicken beta-actin promoter with the upstream cytomegalovirus enhancer (pCAGGS) followed by a floxed lacZ neo fusion cassette with three SV40 poladenylation sites, a constitutively active form of Akt1 with an HA epitope, an IRES site, and enhanced GFP. Cre-mediated recombination allows for expression of the constitutively active Akt1 and EGFP. Two lines were generated (42 and 56) that both had strong homogeneous lacZ expression. This is a representative record for these two lines. (J:136227)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
