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ES cells carrying the Rr320tm1.1Mkg allele, which has most of the Rr320 (Hbb-ar) region replaced with a loxP site, were targeted in cis with a construct that replaced the upstream HS-62.5 element with a loxP site flanked neomycin selection cassette. This substitution removed nucleotides -63238 through -59669, relative to the start site of the Hbb-y gene. Transient expression of Cre recombinase eliminated the entire genomic sequence between the newly inserted floxed neo cassette and the loxP site present from the Rr320rtm1.1Mkg allele. This deletion removes genes Olfr64, Olf65, Olf66, and almost all of the Hbb-ar region. (J:139198)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
