A loxP site was inserted upstream of exon 11 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 15. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 11 through 15 floxed. (J:139510)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count