Scn8a^M1Btlr

This mutation was identified by its behavioral phenotype among G3 progeny of an ENU mutagenized male mouse. It was mapped to Chr 15 and found to correspond to a G to T transversion at nucleotide position 2919 of the gene (Genbank: NM_001077499). This is predicted to result in replacement of tryptophan by leucine at amino acid position 935 (W935L), which resides in the pore loop between helices S5 and S6 of domain II. (J:139714)