The gene lacking the sequence that encodes the TRAF3-binding domain, preceded by a floxed neo STOP cassette and followed by an frt-flanked IRES-EGFP cassette, was knocked into the locus to achieve cre-inducible, ubiquitous expression. Cre mediated removal of the STOP cassette is required for expression. (J:139293, J:157820)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count