A cassette containing a puromycin resistance gene, an Hprt minigene, and an agouti minigene was inserted 3' of exon 6. Following this insert, exons 3-6 were duplicated. Northern blot analysis indicated the complete absensence of mRNA transcribed from this allele in liver RNA. (J:138734)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count