LoxP sites were inserted around exon 8 and a frt-flanked neomycin cassette was inserted in the intronic sequence between exons 8 and 9. Progeny were crossed with transgenic mice expressing Flp-recombinase in order to remove the neomycin resistance cassette. (J:139245)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count