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Three highly conserved DNA-binding residues encoded in exon 6 (Arg-Glu-Arg at positions 195-197) were mutated to alanine residues. A floxed neo cassette was also inserted upstream of exon 6. Transient expression of Cre recombinase excised the neo cassette leaving behind a loxP site. The mutant protein was expressed at endogenous levels in the fetal liver, was localized to cellular nuclei, but lacked the ability to bind DNA. (J:139179)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
