Log In|Sign Up
EN
A luciferase coding sequence and cDNA encoding human SOD1 with a G93A amino acid substitution were cloned into a plasmid containing a bi-cistronic tetracycline operator promoter (BiTetO). The construct was injected into micronuclei. Five lines were generated. Transgene expression was determined by luciferase activity in isolated fibroblasts transfected with a CMV-tTA plasmid. Analysis using anti-SOD1 and -luciferase antibodies was also performed on fibroblasts. (J:138761)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
