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The transgene strain was created by microinjection of the human BAC RPCI11-566K11 into embryos homozygous for Mc1re. The BAC contains 146 kb of sequence with the complete human gene MC1R and includes at least 4 other genes. Quantitative RT-PCR on skin samples indicated that expression of the human MC1R was 9- to 20-fold lower than the endogenous mouse gene. (J:129904)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
