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A transgene encoding a form of Akt1 that includes a Src-derived myristoylation signal and a hemagluttinin epitope tag was put under the control of the Lck promoter. Myristoylation of Akt1 causes it to be constitutively active. Transgene expression was detected in the thymus. This line had moderate expression of the transgene compared to one lower expressing line and one higher expressing line that was subsequently loss to thymic lymphomas. (J:73487)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
