Tg(TACSTD1)02Leij

A transgenic construct containing the human tumor-associated calcium signal transducer 1 gene (TACSTD1), isolated from a BAC clone, was injected into fertilized FVB/NHsd mouse eggs. Founder line 02 (BACF2) was subsequently established. Transgene expression is directed to the membrane of epithelial cells and is detected in various epithelia in kidney, airways, bile ducts, GI tract (epithelium of villi and crypts of small and large intestine) and in glandular epithelium of reproductive system (epithelium of endometrium, testis tubuli seminifer and epithelium of fallopian ducts), as well as in Hassall's corpuscles in the thymus. Pattern is similar to human expression patterns in normal and tumor tissues. (J:69638)