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A recombined human mu heavy chain immunoglobulin gene was used in the construction of a transgene. Downstream of the last mu constant region exon, two deletions eliminated the cleavage /poly(A) addition signal so that only the membrane bound form IgM would be expressed. Two transgene lines were created, SA and SD, with the SA line having higher expression. Transgene expression was detected by RT-PCR in the spleen and brain of both transgenic lines. (J:131938)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
