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A yeast artificial chromosome was constructed with a 220-kb insert of the human IgH locus. This insert contained in germline configuration the mu and delta constant regions, the intronic enhancer, all six functional J-h regions, the entire D complex, and the five most proximal variable gene segments. An HPRT mini-gene was included downstream of the constant regions to aid targeting. Line 2B had one copy of the YAC intergrate into the mouse genome and was one of 7 lines generated. Southern blotting confirmed that the YAC integrated without any recombination events occurring. (J:23827)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
