Krt33a^Plsh

This mutation, discovered by its visible phenotype among G1 progeny of an ENU-mutagenized male mouse, corresponds to a T-to-G transversion at nucleotide position 759 of the gene, in the fourth of seven total exons. This substitution results in replacement of tyrosine by aspartic acid at amino acid position 232 (Y323D), in the 2A alpha-helical rod subdomain of the keratin protein. (J:137498)