Log In|Sign Up
EN
A floxed neo cassette was inserted within intron 4, and a specific mutation in exon 4 was introduced by homologous recombination. Mutation resulted in one site of JNK phosphorylation (Thr-112) in exon 4 to be substituted with an Ala (T112A). The neo cassette was then excised with cre recombines leaving a single loxP site in intron 4. Expression of normal amounts of mutant proteins was confirmed by immunoblot. (J:137061)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
