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The coding sequence for rtTA was inserted into the 5'-UTR along with a floxed neomycin selection cassette. The neo selection cassette was eliminated in founder line 7A3 by crossing properly targeted mice to Tg(MMTV-cre)1Mam transgenic animals. When mice were given doxycycline, transgene expression was restricted to mammary epithelial cells as determined by crosses with two different rtTA reporter strains. (J:148684)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
