Four amino acids within the exon 1 of the mouse sequence were converted to the corresponding human sequence and introduced by targeted homologous recombination with loxP flanked neo cassette place in intron 1. The neo cassette was removed either by crossing with deleter cre expressing strain or by transient transfection with cre. (J:136269)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Nucleotide substitutions
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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