A loxP site was inserted upstream of exon 1 and a floxed neo cassette downstream of exon 1. Transient expression of cre in ES cells was used to emove the neo cassette leaving exon 1 floxed. (J:130487)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count