A floxed neo cassette was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 1. Transient cre expression in the ES cells was used to remove the neo cassette leaving exon 1 floxed. (J:130487)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count