A loxP site was inserted upstream of exon 21 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 22. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 21 and 22 floxed. (J:136305)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count