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5.9 kb of genomic DNA encompassing the CpG island and first five exons of the gene were replaced with a loxP-flanked hygromycin-thymidine kinase selection cassette. Transient expression of cre recombinase in correctly targeted ES cells excised the selection cassette, leaving behind a single loxP site. Gene inactivation was confirmed by immunoblotting of testicular lysates. (J:140402)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
