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The Mir106b, Mir93, and Mir25 genes were replaced by an Frt-flanked neomycin cassette. No homozygous mutants are obtained if the neomycin is left in place, but Flp-mediated deletion of neo produces phenotypically normal homozygous mice. Since the Mirn106b-25 cluster resides in the 13th intron of the Mcm7 gene, these results suggest that the neomycin cassette interferes with expression of Mcm7. (J:134861)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
