A floxed neo cassette was inserted downstream of exon 4 and an additional loxP site was inserted upstream of exon 3. Transient cre expression in ES cells removed the neo cassette by cre-mediated recombination leaving exons 3 and 4 floxed. (J:135811)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count