Tg(GPD1)3Bir

The transgene comprises 12.3 kb of human genomic DNA containing the GPD1 gene, consisting of 3.5 kb of 5' flanking sequence, the 7.6 kb protein-coding region and 1.2 kb of 3' flanking DNA. The 5' flanking sequence includes the proximal and distal promoter regions. Founder line 3 (GPDH-B) has approximately 4 copies of the transgene. The transgene is expressed at higher levels in the cerebral cortex and kidney than the endogenous gene. (J:135002)