LoxP sites were inserted upstream and downstream of exon 22. An frt-flanked neo cassette was inserted downstream of exon 22 and was removed by transient flp-mediated recombination in ES cells. (J:136030)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count