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Exon 2 was replaced with an exon 2 containing a nucleotide substitution that resulted in the amino acid substitution of alanine for serine at position 112 (S112A). A floxed neo cassette downstream of the modified exon 2 used for selection purposes was removed by cre-mediated recombination in ES cells. This mutant version of PPARgamma is nonphosphorylatable and has more biological activity. (J:135904)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
