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A transgenic construct containing the entire mouse (AKR/J strain) H2-Aa kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos. Two lines Aalpha10 and Aalpha26 were generated. Line 26 was crossed to mice carrying Tg(H2-Ab1)62Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 46 was established (Aalpha46). S1-mapping shows normal patterns of high expression in spleen, lung and thymus. (J:110897)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
