Exons 4 through 8, encoding the DNA binding, leucine zipper, and marked box domains were replaced via homologous recombination with a floxed PGK-neo cassette that includes a stop codon at the beginning. Western blot analysis of homozygous MEFs confirmed the absence of protein expression. (J:134271)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count