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An enhancer element that lies far downstream of the C-kappa gene segment was targeted by homologous recombination. This "further downstream enhancer element" (Ed) is located 8 kb downstream from another downstream enhancer, the E3' enhancer element (Rr159). The 1.2kb Ed element was flanked by loxP sites with a floxed neomycin selection cassette also being placed immediately downstream. Founder mice were bred with cre transgenic mice to remove the Ed element and the selection cassette. Deletion of the Ed element was confirmed through Southern blotting. (J:134885)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
