The cDNA for bovine PRKG1 isoform alpha was inserted immediately downstream of the start methionine followed by a neo cassette. The insertion results in the mutation of serine 2 of the bovine cDNA to an arginine. Expression of the bovine protein in smooth muscle cells was confirmed by western blot analysis. (J:134928)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count