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Point mutations were introduced into codons 12, 19, 26, and 33 of exon 1 alpha, converting essential leucine zipper leucine/isoleucine residues into alanines. In addition a self-excising protamine-cre neo cassette was introduced into the intron after exon 1 alpha leaving behind a single loxp site. Immunoblot analysis of homozygous blood vessels detected expression of only the mutant protein. Pull down assay analysis confirmed the disruption of the interaction of the mutant protein with Mprip (J:134634)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
