A targeting vector was designed to insert a loxP-flanked tau-lacZ cassette followed by a neo cassette and then a third loxP site into the 5'-UTR of the targeted gene. Cre mediated recombination then removed the neo cassette leaving the floxed tau-lacZ cassette intact. (J:134516)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count