The CAG promoter (chicken beta actin promoter) was used to drive ubiquitous expression of a flag-tagged Has2 cDNA preceded by a floxed neo cassette with a polyadenylation sequence. Cre-mediated recombination is required to remove the neo cassette and allow for Has2 expression. Seven lines were established with line HA-99 examined further. (J:118655)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count