The variable regions 4 and 3 were replaced with a floxed neo cassette and the variable regions 4 and 2 with a 5' loxP site. Transient cre expression in ES cells was used to remove the neo cassette leaving the inserted variable regions 4 and 2 floxed. (J:133974)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count