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The rat insulin promoter was placed upstream of the adenovirus early region 3 (E3) with a 202-bp deletion of the gp19K gene and the sequences for the 10.4K, 14.5K, 14.7K (and 11.6K) genes retained. This construct was injected into NOD/ShiLtDvs oocytes. RT-PCR analysis of mRNA from pancreatic beta cells of mice bearing this transgene demonstrates expression of the 10.4K, 14.5K, 14.7K and 11.6K genes, but detects no gp19 transcripts. (J:83195)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
