The gene trap vector pGT1lxf that contains the beta-geo cassette was inserted between exon 10 and 11. This allele is a reporter allele and a hypomorphic allele with reduced expression in the brain (80% reduction), liver (70% reduction) and spleen (50% reduction) of homozygotes as detected by semi-quantitative RT-PCR. (J:133892)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count