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A neo cassette was inserted into exon 4 interrupting amino acid thr-413 and leu-414. The absence of protein products was confirmed by western blot analysis on liver extracts. Northern blot analysis confirmed the absence of all Ugt1a family RNAs in homozygous liver. Conjugation activity using bilirubin or T4 as substrates was absent from homozygous liver extracts. (J:133790)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
