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The transgene construct contains a 5.3 kb fragment of genomic DNA encoding the entire mouse Gpx1 gene with about 2 kb of 5' flanking sequence. The construct was microinjected into fertilized B6C3F1 x B6C3F1 oocytes. Two lines with additional copies of the Gpx1 gene were generated and line 41 was chosen for the original study. Increased Gpx1 mRNA expression was detected in RNA blots in eye, brain, lung, muscle, spleen, tongue, and most dramatically in heart of transgenic animals. Gpx1 activity in heart was found to be increased by 500% relative to wild-type controls. Activity was increased in other tissues also. (J:127782)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
