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This transgene contains a human PAC with 110 kb long fragment with the entire human PRNP gene and flanking genes (such as DOPPLE). Three lines were created with 1, 3 and 5 copies of the PAC at one integration site. Line 650 contains 5 copies. Expression in the brain is 6-fold higher than in the null background. (J:131324)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
