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The neuron-specific promoter elements of the mouse Thy1 gene drive expression of the 383 amino acid isoform of human tau - the shortest of the isoforms having four microtubule binding repeats (0N4R) - in which proline is replaced by serine at amino acid position 301 of the protein (P301S). Immunoblot analysis demonstrates the presence of human tau at approximately twice the level of the combined endogenous mouse tau proteins in brains and spinal cords of 5-6 month old homozygous transgenic mice. (J:108870)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
