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The transgene was made from a 10-kb mouse genomic DNA fragment, derived from the CD-1 genomic cosmid clone cos2W3a, containing the Hoxc11 coding region with 2 kb of upstream and 5 kb of downstream flanking DNA. The E. coli lacZ coding sequence was inserted in-frame at an Eag1 restriction site in exon 1, replacing an internal Eag1 DNA fragment. Expression of beta-galactosidase from the transgene in 11.5-13.5 dpc embryos, detected by Xgal staining, recapitulates that of endogenous HOXC11 in the hindlimb and posterior proximal forelimb. (J:61447)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
