A loxP site was inserted into exon 1, 49 bp upstream of the transcription start site. A loxP flanked neomycin cassette was inserted into intron 1. Gene expression was unaffected as determined by immunoblot analysis of various tissues from homozygotes. (J:132516)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count